The effects of glycemic index on prostate cancer progression in a xenograft mouse model.

Gloria Cecilia GalvánEverardo MaciasSergio SandersAdela Ramirez-TorresShannon StockSungyong You Céline E RieraPatrick TamukongStephanie A Smith-WarnerJeanine M GenkingerDaniel J LuthringerMichael R Freeman Stephen J Freedland

Published in: Prostate cancer and prostatic diseases (2023)

In this single mouse xenograft model, consuming a low GI diet did not delay PC growth or survival vs. a high GI diet despite suggestions of decreased activation of the insulin/IGF-1 pathway. These data suggest that improving carbohydrate quality alone while consuming a high carbohydrate diet may not effectively slow PC growth.

Keyphrases

prostate cancer
weight loss
physical activity
type diabetes
mouse model
glycemic control
radical prostatectomy
electronic health record
big data
machine learning
metabolic syndrome
binding protein
cell proliferation
growth hormone