Novel rat model of multiple mitochondrial dysfunction syndromes (MMDS) complicated with cardiomyopathy.

Yahao LingJiaxin MaXiaolong QiXu ZhangQi KongFeifei GuanWei DongWei ChenShan GaoXiang GaoShuo PanYuanwu MaDan LuLianfeng Zhang

Published in: Animal models and experimental medicine (2021)

We have established a rat model of MMDS complicated with cardiomyopathy, it can also be used as model of myocardial energy metabolism dysfunction and mitochondrial cardiomyopathy. This model can be applied to the study of the mechanism of energy metabolism in cardiovascular diseases, as well as research and development of drugs.

Keyphrases

heart failure
cardiovascular disease
oxidative stress
type diabetes
metabolic syndrome
coronary artery disease
cardiovascular risk factors