Investigating colour vision and its structural correlates 15 years following a first demyelinating event.
Charmaine YamWallace J BrownleeFerran Prados CarrascoAhmed E OthmanOlga CiccarelliPublished in: Journal of neurology, neurosurgery, and psychiatry (2024)
Colour vision was impaired in unaffected eyes, especially in SPMS. GCIPL thinning underpinned this impairment more than pRNFL, suggesting neuroaxonal loss as the pathobiological substrate. The correlation between worse colour vision and increasing T2 lesion load suggests that colour dysfunction reflects overall greater disease burden. Quantitative evaluation of colour vision in addition to OCT may be useful to assess disease severity in patients after a first demyelinating event.