Young adult-born neurons improve odor coding by mitral cells.
H Shani-NarkissA VinogradItamar Daniel LandauG TasakaNadav YayonS TerletskyM GroysmanI MaorH SompolinskyAdi MizrahiPublished in: Nature communications (2020)
New neurons are continuously generated in the adult brain through a process called adult neurogenesis. This form of plasticity has been correlated with numerous behavioral and cognitive phenomena, but it remains unclear if and how adult-born neurons (abNs) contribute to mature neural circuits. We established a highly specific and efficient experimental system to target abNs for causal manipulations. Using this system with chemogenetics and imaging, we found that abNs effectively sharpen mitral cells (MCs) tuning and improve their power to discriminate among odors. The effects on MCs responses peaked when abNs were young and decreased as they matured. To explain the mechanism of our observations, we simulated the olfactory bulb circuit by modelling the incorporation of abNs into the circuit. We show that higher excitability and broad input connectivity, two well-characterized features of young neurons, underlie their unique ability to boost circuit computation.
Keyphrases
- induced apoptosis
- spinal cord
- cell cycle arrest
- mitral valve
- young adults
- childhood cancer
- resting state
- left ventricular
- white matter
- high resolution
- low birth weight
- endoplasmic reticulum stress
- functional connectivity
- gestational age
- cell death
- signaling pathway
- spinal cord injury
- preterm infants
- multiple sclerosis
- aortic stenosis
- cell proliferation
- coronary artery disease
- preterm birth
- cerebral ischemia
- mass spectrometry
- aortic valve