Targeting Patient-Derived Orthotopic Gastric Cancers with a Fluorescent Humanized Anti-CEA Antibody.

Kristin E CoxMichael A TurnerThinzar M LwinSiamak AmirfakhriKaitlyn J KellyMojgan HosseiniPradipta GhoshMarygorret ObonyoRobert M HoffmanPaul J YazakiMichael Bouvet

Published in: Annals of surgical oncology (2024)

Humanized anti-CEA (M5A) antibodies conjugated to fluorescent dyes provide bright and specific labeling of gastric cancer PDOX models. This tumor-specific fluorescent antibody is a promising potential clinical tool to detect the extent of disease for the determination of resectability as well as to visualize tumor margins during gastric cancer resection.

Keyphrases

quantum dots
living cells
label free
monoclonal antibody
fluorescent probe
photodynamic therapy
cancer therapy
human health
mass spectrometry
solid phase extraction
high resolution