Genomic Analysis of Foxp3 Function in Regulatory T Cells.

Published in: Journal of immunology (Baltimore, Md. : 1950) (2023)

Regulatory T (Treg) cells are critical for tolerance to self-antigens and for preventing autoimmunity. Foxp3 has been identified as a Treg cell lineage-defining transcription factor controlling Treg cell differentiation and function. In this article, we review the current mechanistic and systemic understanding of Foxp3 function enabled by experimental and computational advances in high-throughput genomics.

Keyphrases

regulatory t cells
dendritic cells
single cell
transcription factor
high throughput
induced apoptosis
oxidative stress
signaling pathway
stem cells
cell cycle arrest
cell proliferation
bone marrow
pi k akt
cell fate
genome wide identification