Emerging Perspectives on the Set of Conditions That Lead to the Emergence of Metabolic Syndrome.
Bogdan M TarcăuLaura Gratiela Gratiela VicasLorena FilipFlorin MaghiarMircea ȘandorAnnamaria PallagTunde JurcaMariana Eugenia MureșanEleonora MarianPublished in: Journal of personalized medicine (2023)
Metabolic syndrome, as a medical condition, presents multifactorial complexity that is characterized by the resulting damage from genetic, environmental, and lifestyle factors (presence or absence of physical activity, food choices). Thus, metabolic syndrome qualifies unequivocally as a medical condition in which there are, simultaneously, several independent metabolic risk factors, namely, abdominal obesity, high triglyceride level, low HDL cholesterol level, arterial hypertension, and high glycemic level. Although age, sex, socio-economic status, and the precise definition of metabolic syndrome all influence the prevalence and risk of developing the condition, clinical and epidemiological studies clearly show that central obesity, as measured by an increased abdominal circumference, is the main risk factor. Thus, due to the growing global incidence of obesity, there has been an increase in the incidence of metabolic syndrome. Starting with obesity, all other metabolic risk factors are influenced: for example, as a result of insulin resistance with hyperglycemia, diabetes is linked to an increased risk of cardiovascular disease due to increased abdominal circumference. Through this review, we aimed to highlight the latest research studies and dietary nutritional interventions useful in the prevention of this disease but also implementation strategies for primary prevention among the healthy population.
Keyphrases
- metabolic syndrome
- risk factors
- insulin resistance
- cardiovascular disease
- type diabetes
- physical activity
- uric acid
- body mass index
- cardiovascular risk factors
- high fat diet induced
- high fat diet
- healthcare
- glycemic control
- polycystic ovary syndrome
- arterial hypertension
- primary care
- oxidative stress
- weight loss
- genome wide
- depressive symptoms
- weight gain
- coronary artery disease
- gene expression
- case control
- body weight
- sleep quality
- cardiovascular events
- risk assessment