Quantitative accuracy of (177)Lu SPECT reconstruction using different compensation methods: phantom and patient studies.

The highest cRC values were achieved by applying ARS compensation during reconstruction. The results were notably higher than those using attenuation correction alone. Similarly, higher activity estimates and thus higher absorbed dose estimates were found in patient data when all compensation methods were applied. ARS improved cRC especially in small-sized sources, and it thus might aid tumour dosimetry for (177)Lu PRRT treatments.