Synthesis of Functionalized Azepines via Cu(I)-Catalyzed Tandem Amination/Cyclization Reaction of Fluorinated Allenynes.

Anna N PhilippovaDaria V VorobyevaPavel S GribanovIvan A GodovikovSergey N Osipov

Published in: Molecules (Basel, Switzerland) (2022)

An efficient method for the selective preparation of trifluoromethyl-substituted azepin-2-carboxylates and their phosphorous analogues has been developed via Cu(I)-catalyzed tandem amination/cyclization reaction of functionalized allenynes with primary and secondary amines.

Keyphrases

molecularly imprinted
room temperature
molecular docking
quantum dots
aqueous solution
metal organic framework
solid phase extraction
electron transfer
ionic liquid
tandem mass spectrometry
simultaneous determination