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Fatigue in primary Sjögren's syndrome: A proteomic pilot study of cerebrospinal fluid.

Eivind LarssenCato BredeAnne HjelleAnne Bolette TjensvollKatrine Brække NorheimKjetil BårdsenKristin JonsdottirPeter RuoffRoald OmdalMari Mæland Nilsen
Published in: SAGE open medicine (2019)
Most of the discriminatory proteins have important roles in regulation of innate immunity, cellular stress defense, and/or functions in the central nervous system. These proteins and their interacting protein networks may therefore have central roles in the generation and regulation of fatigue, and the findings contribute with evidence to the concept of fatigue as a biological phenomenon signaled through specific molecular pathways.
Keyphrases
  • cerebrospinal fluid
  • sleep quality
  • depressive symptoms
  • rheumatoid arthritis
  • protein kinase
  • heat stress