Effects of Cycloastragenol on Alzheimer's Disease in Rats by Reducing Oxidative Stress, Inflammation, and Apoptosis.
Kadi M AlharbiShahad A AlshehriWasayf A AlmarwaniKhulud K AljohaniAjwan Z AlbalawiAreej S AlatawiShekha M Al-AtwiLama S AlhwytyHanan M HassanMohammed M H Al-GayyarPublished in: Current Alzheimer research (2024)
Cycloastragenol improved the structure of the hippocampus in rats with AD. It enhanced the outcomes of behavioral tests, decreased the concentration of AChE in the brain, and exerted antioxidant and anti-inflammatory effects. Antiapoptotic effects were also noted, leading to significant improvements in cognitive function, memory, and behavior in treated rats.
Keyphrases
- oxidative stress
- diabetic rats
- dna damage
- ischemia reperfusion injury
- induced apoptosis
- endoplasmic reticulum stress
- cognitive decline
- multiple sclerosis
- white matter
- cerebral ischemia
- cell death
- signaling pathway
- anti inflammatory
- cell proliferation
- brain injury
- cell cycle arrest
- subarachnoid hemorrhage
- newly diagnosed
- prefrontal cortex