YAP mediates the interaction between the Hippo and PI3K/Akt pathways in mesangial cell proliferation in diabetic nephropathy.
Xuan QianLinlin HeMeng HaoYuan LiXizhi LiYiqi LiuHong JiangLiu XuChengcheng LiWenya WuLei DuXiaoxing YinQian LuPublished in: Acta diabetologica (2020)
The Hippo pathway is inhibited under diabetic conditions, leading to YAP activation and promoting MC proliferation. The PI3K/Akt pathway is activated through the inhibitory effect of YAP on its repressor, PTEN. Finally, activation of the PI3K/Akt pathway inhibits the Hippo pathway, resulting in nuclear YAP accumulation and accelerating MC proliferation and DN formation.