Pangenome and genomic signatures linked to the dominance of the lineage-4 of Mycobacterium tuberculosis isolated from extrapulmonary tuberculosis patients in western Ethiopia.
Basha ChekesaHarinder SinghNorberto Gonzalez-JuarbeSanjay VasheeRosana Wiscovitch-RussoChristopher L DupontMusse GirmaOudessa Kerro DegoBalako GumiGobena AmeniPublished in: PloS one (2024)
Apart from host and environmental factors, the sublineage of L4 employs distinct virulence factors for successful dissemination in western Ethiopia. Given that the functions of these newly identified genes are not well understood, it is advisable to experimentally validate their roles, particularly in the successful transmission of specific L4 sublineages over others.
Keyphrases
- mycobacterium tuberculosis
- end stage renal disease
- chronic kidney disease
- south africa
- ejection fraction
- genome wide
- newly diagnosed
- escherichia coli
- pseudomonas aeruginosa
- pulmonary tuberculosis
- staphylococcus aureus
- peritoneal dialysis
- prognostic factors
- emergency department
- dna methylation
- antimicrobial resistance
- copy number
- gene expression
- hiv aids
- transcription factor
- patient reported outcomes
- adverse drug
- antiretroviral therapy
- electronic health record
- genome wide identification