Osteosarcoma Cells Secrete CXCL14 That Activates Integrin α11β1 on Fibroblasts to Form a Lung Metastatic Niche.

Yanyang Xu Chuangzhong Deng Hongmin Chen YiJiang Song Huaiyuan Xu Guohui Song Xinliang Wang Tian-Qi Luo Weiqing Chen Jiahui Ma Anyu Zeng Shujing Huang Zhihao Chen Jianchang Fu Ming Gong Yi Tai Anfei Huang Huixiong Feng Jinxin Hu Xiaojun Zhu Qinglian Tang Jinchang Lu Jin Wang

Published in: Cancer research (2024)

Cooperation between stem-like osteosarcoma cells and fibroblasts mediated by a CXCL14-integrin α11β1 axis creates a tumor-supportive lung metastatic niche and represents a therapeutic target to suppress osteosarcoma metastasis.

Keyphrases

induced apoptosis
cell cycle arrest
squamous cell carcinoma
small cell lung cancer
endoplasmic reticulum stress
cell death
extracellular matrix
oxidative stress
signaling pathway
cell migration