Rosiglitazone polarizes microglia and protects against pilocarpine-induced status epilepticus.

Jing Peng Kan Wang Weiwei Xiang Yan Li Yong Hao Yang-Tai Guan

Published in: CNS neuroscience & therapeutics (2019)

Rosiglitazone reverses microglial polarization in the brains of SE mice and also affords neuroprotection against pilocarpine-induced status epilepticus without inducing significant changes in brain inflammation.

Keyphrases

high glucose
diabetic rats
inflammatory response
oxidative stress
neuropathic pain
drug induced
brain injury
cerebral ischemia
spinal cord injury
multiple sclerosis
spinal cord
insulin resistance
high fat diet induced
blood brain barrier
skeletal muscle
subarachnoid hemorrhage