Myocardial interstitial levels of serotonin and its major metabolite 5-hydroxyindole acetic acid during ischemia-reperfusion.

Cheng-Kun DuDong-Yun ZhanTsuyoshi AkiyamaTadakatsu InagakiToshiaki ShishidoMikiyasu ShiraiJames T Pearson

Published in: American journal of physiology. Heart and circulatory physiology (2016)

By monitoring myocardial interstitial levels of 5-HT and its metabolite, 5-hydroxyindole acetic acid, we investigated 5-HT kinetics during myocardial ischemia-reperfusion. 5-HT accumulates but 5-HT degradation is suppressed during ischemia. After reperfusion, 5-HT degradation is enhanced and this degradation is dependent on monoamine oxidase activity but not fluoxetine-sensitive uptake transporter.

Keyphrases

left ventricular
heart failure
coronary artery disease
acute coronary syndrome
atomic force microscopy
subarachnoid hemorrhage