A photo-responsive chemical modulation of m6A RNA demethylase FTO.

Ling LanYing-Jie SunLi LiuLiang Cheng

Published in: Chemical communications (Cambridge, England) (2021)

The adenine N6-methylation m6A is a crucial modification that is associated with several biological functions. One of the two m6A demethylases FTO has arisen as an attractive target for the development of novel cancer therapies. Here, we describe a new design, synthesis and evaluation of a photo-responsive and selective inhibitor of FTO.

Keyphrases

cancer therapy
papillary thyroid
squamous cell
dna methylation
electron transfer
gene expression
squamous cell carcinoma
lymph node metastasis
nucleic acid