A panel of CSF proteins separates genetic frontotemporal dementia from presymptomatic mutation carriers: a GENFI study.
Sofia BergströmLinn ÖijerstedtJulia RemnestålJennie OlofssonAbbe UllgrenHarro SeelaarJohn C van SwietenMatthis SynofzikRaquel Sanchez-ValleFermin MorenoElizabeth FingerMario MasellisCarmela TartagliaRik VandenbergheRobert LaforceDaniela GalimbertiBarbara BorroniChris R ButlerAlexander GerhardSimon DucharmeJonathan D RohrerAnna MånbergCaroline GraffPeter Nilssonnull nullPublished in: Molecular neurodegeneration (2021)
In conclusion, we have identified several proteins with the combined potential to separate affected individuals from unaffected individuals, as well as proteins with potential to contribute to the separation between presymptomatic individuals and mutation non-carriers. Further studies are needed to continue the investigation of these proteins and their potential association to the pathophysiological mechanisms in genetic FTD.