NTRK1 Fusions identified by non-invasive plasma next-generation sequencing (NGS) across 9 cancer types.
Christian C RolfoAlexander E DrilonDavid HongCaroline McCoachAfshin DowlatiJessica J LinAlessandro RussoAlison M SchramStephen V LiuJorge J NievaTimmy NguyenShahrooz EshaghianMichael MorseScott GettingerMohammad MobayedSarah GoldbergEmilio Araujo-MinoNeelima VidulaAditya BardiaJanakiraman SubramanianDeepa SashitalThomas StinchcombeLesli KiedrowskiKristin PriceDavid R GandaraPublished in: British journal of cancer (2021)
Plasma ctDNA represents a rapid, non-invasive screening method for this rare genomic target that may improve identification of patients who can benefit from TRK-targeted therapy and potentially identify subsequent on- and off-target resistance mechanisms.