Red Raspberry Polyphenols Attenuate High-Fat Diet-Driven Activation of NLRP3 Inflammasome and its Paracrine Suppression of Adipogenesis via Histone Modifications.

Rong FanMikyoung YouAshley M ToneyJudy KimDavid GiraudYibo XianFeng YeLiwei GuAmanda E Ramer-TaitSoonkyu Chung

Published in: Molecular nutrition & food research (2019)

RR polyphenols from pulp and whole fruit serve as an inhibitor for NLRP3 inflammasome activation and an epigenetic modifier to regulate adipogenesis, which confers resistance against diet-induced obesity and metabolic dysfunction.

Keyphrases

nlrp inflammasome
high fat diet
insulin resistance
high fat diet induced
adipose tissue
dna methylation
metabolic syndrome
type diabetes
weight loss
gene expression
skeletal muscle
oxidative stress
weight gain
body mass index