Somatic and Germline Genomic Alterations in Very Young Women with Breast Cancer.

Adrienne G WaksDewey KimEsha JainCraig SnowGregory J KirknerShoshana M RosenbergCoyin OhPhilip D PoorvuKathryn J Ruddy Rulla M TamimiJeffrey PeppercornLidia Schapira Virginia F BorgesSteven E ComeElena F BrachtelEllen WarnerLaura C CollinsAnn H PartridgeNikhil Wagle

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

Somatic alterations in three genes (PIK3CA, GATA3, and ARID1A) occur at different frequencies in young versus older women with luminal A breast cancer. Additional investigation of these genes and associated pathways could delineate biological susceptibilities and improve treatment options for young patients with breast cancer. See related commentary by Yehia and Eng, p. 2209.

Keyphrases

middle aged
copy number
genome wide
transcription factor
physical activity
bioinformatics analysis
dna repair
dna damage
protein kinase
drug induced