Allergen exposure boosts peripheral Th9 responses in patients with local allergic rhinitis.

Francisca PalomaresAlmudena Testera-MontesCarlos Jose ArandaCarmen Alba-LineroRocío Sáenz de Santa María-GarcíaGuillermo Bentabol-RamosCristobalina MayorgaMaria Jose TorresCarmen RondonIbon Eguiluz-Gracia

Published in: International forum of allergy & rhinology (2023)

Intranasal allergen exposure increases peripheral total Th2 and Th9 cells in patients with local allergic rhinitis (LAR). Peripheral T-cell response seems dominated by Th9 cells in patients with LAR, whereas Th2 responses prevail in patients with allergic rhinitis. Our results identify Th9 cells as potential therapeutic targets for patients with LAR.

Keyphrases

allergic rhinitis
induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
oxidative stress
pi k akt
signaling pathway
cell proliferation
climate change