Tertiary lymphoid structure related B-cell IgE isotype switching and secondary lymphoid organ linked IgE production in mouse allergy model.

Dmitrii Borisovich ChudakovDmitrii Yuryevich RyasantsevDaria Sergeevna TsaregorotsevaOlga Dmitrievna KotsarevaGulnar Vaisovna FattakhovaElena Viktorovna Svirshchevskaya

Published in: BMC immunology (2020)

Tertiary lymphoid structures possess unique environment where B-cell antibody isotype switching to IgE predominantly occurs. This phenomenon is partially explained by hampered proliferation of B-cells in these structures.

Keyphrases

high resolution
signaling pathway
mass spectrometry
atopic dermatitis