HCV resistance compartmentalization within tumoral and non-tumoral liver in transplanted patients with hepatocellular carcinoma.
Maria C SorboLuca CariotiMaria C BellocchiFrancescoPaolo AntonucciDaniele SforzaIlaria LenciMatteo Ciancio ManuelliDaniele ArmeniaFrancesco De LeonardisMartina MilanaTommaso M ManziaMario AngelicoGiuseppe TisoneValeria CentoCarlo F PernoFrancesca Ceccherini-SilbersteinPublished in: Liver international : official journal of the International Association for the Study of the Liver (2019)
Hepatic compartments showed differences in HCV-RNA amount, RASs and genetic variability, with a higher segregation within the tumoral compartment. HBV coinfection influenced the HCV compartmentalization. These results highlight HCV-strain diversifications within the liver, which could explain some of the failures occurring even today in the era of DAAs.