Evaluation of [18F]Fluorothymidine as a Biomarker for Early Therapy Response in a Mouse Model of Colorectal Cancer.

Sara RapicChristel VangestelJeroen VerhaegheDavid ThomaePatrick PauwelsTim Van den WyngaertSteven StaelensSigrid Stroobants

Published in: Molecular imaging and biology (2017)

[18F]FLT positron emission tomography was found to be a suitable biomarker of early tumor response to anti-proliferative treatment, with static imaging not being inferior to full compartmental analysis in our xenograft model. The dynamics of thymidine kinase 1 protein expression and protein activity in low ATP environments merits further investigation.

Keyphrases

positron emission tomography
computed tomography
mouse model
tyrosine kinase
acute myeloid leukemia
high resolution
pet imaging
pet ct
small molecule
mesenchymal stem cells
fluorescence imaging
smoking cessation