Lung Tissue Multi-Layer Network Analysis Uncovers the Molecular Heterogeneity of COPD.

Nuria OlveraJon Sánchez-ValleIker Núñez-CarpinteroJoselyn Rojas-QuinteroGuillaume NoellSandra Casas-RecasensAlen FaizPhilip HansbroAngela GuiraoRosalba LeporeDavide CirilloAlvar AgustíFrancesca PolverinoAlfonso ValenciaRosa Faner

Published in: American journal of respiratory and critical care medicine (2024)

and emphysema can have molecularly distinct small airways and immune response patterns, indicating that different endotypes can lead to similar clinical presentation.

Keyphrases

network analysis
chronic obstructive pulmonary disease
immune response
lung function
cystic fibrosis
single cell
air pollution
dendritic cells
toll like receptor
idiopathic pulmonary fibrosis
single molecule
inflammatory response