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Homeostatic, Non-Canonical Role of Macrophage Elastase in Vascular Integrity.

Mani SalarianMean GhimJakub ToczekJinah HanDar WeissBart SpronckAbhay B RamachandraJae-Joon JungGunjan KukrejaJiasheng ZhangDeaneira LakheramSung-Kwon KimJay D HumphreyMehran M Sadeghi
Published in: Circulation research (2023)
An MMP-12 deficiency/complement activation/NETosis pathway compromises aortic integrity, which predisposes to adverse vascular remodeling and abdominal aortic aneurysm rupture. Considering these new findings, the role of macrophage MMP-12 in vascular homeostasis demands re-evaluation of MMP-12 function in diverse settings.
Keyphrases
  • abdominal aortic aneurysm
  • adipose tissue
  • cell migration
  • aortic valve
  • heart failure
  • left ventricular
  • pulmonary artery
  • pulmonary hypertension
  • coronary artery
  • adverse drug