Roles of BCCIP deficiency in mammary tumorigenesis.

Roberto Droz-RosarioHuimei LuJingmei LiuNing-Ang LiuShridar GanesanBing XiaBruce G HafftyZhiyuan Shen

Published in: Breast cancer research : BCR (2017)

Our data suggest a confounding role of BCCIP deficiency in modulating breast cancer development by enhancing tumor initiation but hindering progression. Furthermore, secondary genetic alternations may overcome the progression suppression imposed by BCCIP deficiency through a synthetic viability mechanism.

Keyphrases

replacement therapy
signaling pathway
electronic health record
gene expression
dna methylation