T cells exhaustion, inflammatory and cellular activity markers in PBMCs predict treatment outcome in pulmonary tuberculosis patients.
Jacob Nii Otinkorang AnkrahFredrick GyilbagrEzekiel Kofi VicarEmmanuel Antwi Boasiako FrimpongRukaya Baanah AlhassanIbrahim Sibdow BaakoAlahaman Nana BoakyeSamuel Addo AkweteyAkosua Bonsu KarikariFelix Kodzo Besah SorvorWilliams WalanaPublished in: Cytokine (2024)
Collectively, the findings of the study suggest that T-cells exhaustion marker particularly CD244, inflammatory markers IL-2, IFN-g and TNF-a, and cellular activity indicators such as Ki67, CD69, GATA-3, CD8 and CD4 are promising markers in monitoring the progress of PTB patients during treatment.