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Late-Stage Heteroarylation of Hetero(aryl)sulfonium Salts Activated by α-Amino Alkyl Radicals.

Eva Maria AlvarezTeresa KarlFlorian BergerLuca TorkowskiTobias Ritter
Published in: Angewandte Chemie (International ed. in English) (2021)
We report a late-stage heteroarylation of aryl sulfonium salts through activation with α-amino alkyl radicals in a mechanistically distinct approach from previously reported halogen-atom transfer (XAT). The new mode of activation of aryl sulfonium salts proceeds in the absence of light and photoredox catalysts, engaging a wide range of hetarenes. Furthermore, we demonstrate the applicability of this methodology in synthetically useful cross-coupling transformations.
Keyphrases
  • ionic liquid
  • visible light
  • highly efficient
  • electron transfer
  • transition metal