Intramolecular hydrogen-bond activation for the addition of nucleophilic imines: 2-hydroxybenzophenone as a chemical auxiliary.

Houcine ChoubaneAlberto F Garrido-CastroCuauhtemoc AlvaradoAna Martin-Somer Andrea Guerrero-CorellaMortada DaaouSergio Diaz-Tendero M Carmen Maestro Alberto Fraile José Alemán

Published in: Chemical communications (Cambridge, England) (2018)

The addition of nucleophilic imines, using 2-hydroxybenzophenone as a chemical auxiliary, is presented. An intramolecular six-membered ring via hydrogen bonding that enhances the reactivity and selectivity is the key of this strategy, which is supported by DFT calculations and experimental trials.

Keyphrases

density functional theory
energy transfer
molecular dynamics
molecular dynamics simulations
molecular docking