Subtyping Severe Hypercholesterolemia by Genetic Determinant to Stratify Risk of Coronary Artery Disease.

Alexander S F Berry Laney K Jones Eric J G Sijbrands Samuel S GiddingMatthew T Oetjens

Published in: Arteriosclerosis, thrombosis, and vascular biology (2023)

Genetics-based subtyping for monogenic familial hypercholesterolemia and Lp(a) in those with severe hypercholesterolemia provided better stratification of 10-year incident CAD risk than LDL-C-based stratification.

Keyphrases

coronary artery disease
cardiovascular events
early onset
low density lipoprotein
cardiovascular disease
percutaneous coronary intervention
coronary artery bypass grafting
drug induced
heart failure
copy number
acute coronary syndrome
transcatheter aortic valve replacement