Synergistic interaction between diene valepotriates from Valeriana glechomifolia Meyer (Valerianaceae) and classical antidepressants: an isobolographic analysis.

Liz G MüllerEveline D StolzAndresa H BettiVivian HerzfeldtStela Maris Kuze Rates

Published in: The Journal of pharmacy and pharmacology (2015)

The synergistic interactions between VAL and IMI, DESI and BUP highlight the potential for VAL to serve as adjuvants to antidepressant drugs and suggest that VAL does not directly target the same sites on neuronal transporters as the antidepressants.

Keyphrases

major depressive disorder
cancer therapy
bipolar disorder
drug delivery
drug induced