Impact of Plasmodium vivax malaria and antimalarial treatment on cytochrome P450 activity in Brazilian patients.

Anne Cristine AlmeidaAnna Beatriz Ribeiro EliasMaria Paula MarquesGisely Cardoso de MeloAllyson Guimarães da CostaErick Frota Gomes FigueiredoLarissa Wanderley BrasilFernanda Rodrigues-SoaresWuelton Marcelo MonteiroMarcus Vinicius Guimarães de LacerdaVera Lucia Lanchote Guilherme Suarez-Kurtz

Published in: British journal of clinical pharmacology (2020)

P. vivax malaria and treatment altered CYP2D6 and CYP2C19 metabolic phenotypes. CYP2C19 inhibition is attributed to a higher level of circulating proinflammatory cytokines, while suppression of CYP2D6 is ascribed mainly to chloroquine exposure.

Keyphrases

plasmodium falciparum
end stage renal disease
newly diagnosed
chronic kidney disease
ejection fraction
peritoneal dialysis
patient reported