Serum coding and non-coding RNAs as biomarkers of NAFLD and fibrosis severity.

Stefania Di MauroAlessandra Scamporrino Salvatore PettaFrancesca UrbanoAgnese FilippelloMarco RagusaMaria T Di MartinoFrancesca SciontiStefania GrimaudoRosaria M PipitoneGraziella PriviteraAntonino Di PinoRoberto ScicaliLuca Vittorio ValentiPaola DongiovanniAnna Ludovica FracanzaniAgata M RabuazzoAntonio CraxìMichele PurrelloFrancesco PurrelloSalvatore Piro

Published in: Liver international : official journal of the International Association for the Study of the Liver (2019)

We identified specific serum coding/non-coding RNA profiles in severe and mild NAFLD patients that possibly mirror the molecular mechanisms underlying NAFLD progression towards NASH/fibrosis. TGFB2/TGFB2-OT1 detection improves FIB-4/Fibroscan diagnostic performance for advanced fibrosis discrimination.

Keyphrases

liver fibrosis
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
peritoneal dialysis
early onset
loop mediated isothermal amplification