No evidence so far of a major role of AKT1 and GSK3B in the pathogenesis of antipsychotic-induced tardive dyskinesia.
Anastasia LevchenkoNatalya VyalovaIvan V PozhidaevAnastasiia S BoikoDiana Z OsmanovaOlga Yu FedorenkoArkadiy V SemkeNikolay A BokhanBob WilffertAnton J M LoonenSvetlana A IvanovaPublished in: Human psychopharmacology (2019)
Despite regulation of AKT1 and GSK3B by DRD2, we found no evidence that these two kinases play a major role in the pathogenesis of antipsychotic-induced TD. These results agree with previously published data and necessitate further exploration of other pathogenic mechanisms, such as neurotoxicity due to excessive dopamine metabolism.