Hyperinflammatory syndromes after SARS-CoV-2 mRNA vaccination in individuals with underlying immune dysregulation.
Joseph M RoccoChristina Mallarino-HaegerAttiya H RandolphSusan M RayMarcos C SchechterChrista S ZerbeSteven M HollandIrini SeretiPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)
The development of effective SARS-CoV-2 mRNA vaccines has been a significant accomplishment. Adverse events are extremely rare, but continued surveillance is important, especially in at-risk populations. In 5-patients with preexisting immune dysregulation, hyperinflammatory syndromes, including hemophagocytic lymphohistiocytosis, developed after SARS-CoV-2 mRNA vaccination. Early recognition of this rare condition is essential.