Effect of everolimus on the glucose metabolic pathway in mouse skeletal muscle cells (C2C12).

Kayoko YoshidaChiyo K ImamuraKanako HaraMayumi MochizukiYusuke Tanigawara

Published in: Metabolomics : Official journal of the Metabolomic Society (2017)

The present metabolomic analysis indicates that everolimus impairs glucose metabolism in muscle cells by lowering the activities of glycolysis and the pentose phosphate pathway.

Keyphrases

skeletal muscle
induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
oxidative stress
blood glucose
adipose tissue
cell proliferation
pi k akt