Fabrication of PEGylated Bi 2 S 3 Nanosheets As a Multifunctional Platform for Multimodal Diagnosis and Combination Therapy for Cancer.

It becomes more and more practically relevant but challenging to fabricate single-component omnipotent nanotheranostic agents integrated with multimode imaging and multiple therapeutic functions. In this study, 2D Bi 2 S 3 nanosheets were successfully synthesized in a rapid and environmentally friendly manner and were applied into tumor therapy. The resulting nanosheets exhibit high photothermal conversion efficiency due to their strong broad absorbance in the near-infrared (NIR) window and serve as a nanotheranostic agent for photoacoustic imaging and photothermal cancer therapy. In addition, they also display excellent drug (DOX) delivery capacity for the large surface area and negative electron surface enrichment. Additionally, they have also showed sensitive pH responsiveness for drug releasing, accelerating releasing in acidic environment. Our work for the first time discovers the great potential of using Bi 2 S 3 -PEG nanosheets as a type of 2D nanocarriers in drug delivery and cancer combination therapy.