Does Obstructive Sleep Apnoea Syndrome Influence the Development and Treatment of Diabetic Foot? A Brief Narrative Review.
Evanthia GouveriPaschalis SteiropoulosNikoloas PapanasPublished in: The international journal of lower extremity wounds (2022)
Both obstructive sleep apnoea syndrome (OSAS) and diabetes mellitus (DM) are common conditions that often coexist and share many similar risk factors. Diabetic foot is a common complication of DM, which may lead to lower-limb amputation. OSAS is considered a risk factor for type 2 DM (T2DM). There is also evidence that OSAS may be linked with the development, as well as the healing of diabetic foot. Multiple mechanisms triggered by sleep fragmentation and intermittent hypoxaemia in OSAS could contribute to the development of diabetic foot ulcers (DFUs). More interestingly, emerging evidence implies a favourable impact of continuous positive airway pressure (CPAP) treatment on DFU healing. Healing DFUs and minimising recurrence rates remains a challenge for health care professionals. In this context, management of OSAS might prove a useful therapeutic adjunct for DFUS. However, data is still limited and randomised controlled trials are needed to further explore this interesting potential.
Keyphrases
- positive airway pressure
- obstructive sleep apnea
- lower limb
- sleep apnea
- healthcare
- risk factors
- physical activity
- sleep quality
- glycemic control
- metabolic syndrome
- climate change
- depressive symptoms
- combination therapy
- machine learning
- electronic health record
- high intensity
- replacement therapy
- health information
- data analysis