Ampullary cancer: Evaluation of somatic and germline genetic alterations and association with clinical outcomes.

Winston WongMaeve A LoweryMichael F BergerYelena KemelBarry TaylorAhmet ZehirPreethi SrinivasanChaitanya BandlamudiJoanne ChouMarinela CapanuAnna VargheseKenneth H YuChristine A Iacobuzio-DonahueJinru ShiaDavid S KlimstraWilliam R JarnaginZsofia K StadlerEileen M O'Reilly

Published in: Cancer (2019)

Mutations in multiple somatic and germline genes were identified in this cohort. Significantly, actionable targets were identified in the tumors, and broader testing for PGAs and SAs should be considered for all patients with AC.

Keyphrases

copy number
genome wide
dna repair
papillary thyroid
squamous cell
dna methylation
lymph node metastasis
bioinformatics analysis
gene expression
young adults