A novel syphilis Treponema pallidum lipoprotein peptide antigen diagnostic assay using red cell kodecytes in routine blood centre column agglutination testing platforms.
Suvro Sankha DattaRadhika NagappanDurba BiswasDebapriya BasuKaushik GuptaPradip Kumar MondalAlexander TuzikovNicolai V BovinStephen M HenryPublished in: Vox sanguinis (2024)
TmpA-kodecytes are viable for use as cost-effective serologic reagent red cells for the detection of treponemal antibodies to diagnose syphilis with a high level of specificity in blood centres. This kodecyte methodology also potentially allows for introduction of the reverse-algorithm testing into low-volume laboratories, by utilizing existing transfusion laboratory infrastructure.
Keyphrases
- men who have sex with men
- human immunodeficiency virus
- induced apoptosis
- single cell
- cell cycle arrest
- machine learning
- high throughput
- cell therapy
- cardiac surgery
- clinical practice
- deep learning
- liquid chromatography
- hepatitis c virus
- cell death
- signaling pathway
- respiratory syndrome coronavirus
- acute kidney injury
- label free
- real time pcr
- bone marrow
- structural basis
- solid phase extraction
- sensitive detection