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Reversible light-controlled fluorescence switch of block polymer-grafted carbon dots and cellular imaging.

Shilin YangBo LiaoEnxiang LiangShoujun YiQing Liao
Published in: Soft matter (2022)
A novel type of aggregation-induced emission (AIE) nanoparticles, which are carbon dots (CDs) grafted with block polymer of tetraphenylethylene, spiropyran and N -isopropylacrylamide (CD- g -poly((TPE- co -SPA)- block -NIPAM)), was synthesized. The CD- g -poly((TPE- co -SPA)- block -NIPAM) nanoparticles can emit weak cyan fluorescence in tetrahydrofuran, while showing AIE-enhanced cyan fluorescence in water and solid film. The fluorescence of the CD- g -poly((TPE- co -SPA)- block -NIPAM) nanoparticles can reversibly transform cyan to red with UV/visible light irradiation, and functioned as a reversible fluorescence photoswitch. Importantly, the CD- g -poly((TPE- co -SPA)- block -NIPAM) nanoparticles have low cytotoxicity and, therefore, can be used for imaging in living cells.
Keyphrases
  • living cells
  • single molecule
  • fluorescent probe
  • energy transfer
  • high resolution
  • visible light
  • nk cells
  • mass spectrometry
  • room temperature
  • fluorescence imaging
  • photodynamic therapy