Effects of exercise or metformin on myokine concentrations in patients with breast and colorectal cancer: A phase II multi-centre factorial randomized trial.

Justin C BrownGuillaume SpielmannShengping YangStephanie L E ComptonLee W JonesMelinda L IrwinJennifer A LigibelJeffrey A Meyerhardt

Published in: Journal of cachexia, sarcopenia and muscle (2024)

This pilot study demonstrates that randomization to exercise and metformin elicit unique effects on myokine concentrations in cancer patients. This hypothesis-generating observation warrants further basic, translational and clinical investigation and replication.

Keyphrases

phase ii
high intensity
clinical trial
open label
physical activity
resistance training
placebo controlled
phase iii
double blind