A Bayesian multivariate latent t-regression model for assessing the association between corticosteroid and cranial radiation exposures and cardiometabolic complications in survivors of childhood acute lymphoblastic leukemia: a PETALE study.
Miguel Caubet FernandezSimon DrouinMariia SamoilenkoSophia MorelMaja KrajinovicCaroline LaverdièreDaniel SinnettEmile LevyValérie MarcilGeneviève LefebvrePublished in: BMC medical research methodology (2019)
Our results indicated that combined LD/CRT exposure is a likely determinant of dyslipidemia among cALL survivors. No evidence was found to suggest that high doses of CS lead to additional risk for obesity, insulin resistance, (pre-)hypertension, and dyslipidemia beyond that induced by CRT. The multivariate model selected for analyses was judged globally useful to assess potential exposure-related concomitance of binary outcomes.
Keyphrases
- insulin resistance
- acute lymphoblastic leukemia
- metabolic syndrome
- young adults
- type diabetes
- blood pressure
- adipose tissue
- high fat diet induced
- cardiac resynchronization therapy
- high fat diet
- skeletal muscle
- data analysis
- air pollution
- weight loss
- heart failure
- weight gain
- physical activity
- human health
- glycemic control
- body mass index
- atrial fibrillation
- climate change