Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status.
Cristina MiralpeixAna Cristina RegueraAnna FoschMaria CasasJaume LilloGemma NavarroRafael FrancoJosefina CasasStephen P H AlexanderNúria CasalsRosalía Rodríguez-RodríguezPublished in: British journal of pharmacology (2021)
Our finding that negative regulation of ABHD6 activity, particularly in the hypothalamus, is sensitive to nutritional status throws new light on the characterization and the importance of the proteins involved as potential targets against diseases affecting the CNS.