Neuroretinal and microvascular retinal features in dementia with Lewy body assessed by optical coherence tomography angiography.
Giuseppe Maria AlbaneseMagda GharbiyaGiacomo VisioliMassimiliano PaniguttiAndrea MargarellaEnrico RomanoElvia MastrogiuseppeMicaela Sepe-MontiGiuseppe BrunoFabrizia D'AntonioPublished in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2024)
Impairments in retinal capillaries, especially lower ppVD, might mirror cerebral hypoperfusion in DLB, potentially due to reduced Vascular Endothelial Growth Factor (VEGF) levels and increased α-synuclein. Further investigations are warranted to confirm the causal relationship between these observations, disease severity, and progression, as well as their potential role as biomarkers for DLB.