Fluorescence artifact correction in the thrombin generation assay: Necessity for correction algorithms in procoagulant samples.
William C ChangJoseph W JacksonKellie R MachlusAlisa S WolbergMikhail V OvanesovPublished in: Research and practice in thrombosis and haemostasis (2021)
Our data suggest that correction for substrate consumption and IFE, as offered by the CAT algorithm, is critical for detecting a subset of extremely procoagulant samples, such as elevated prothrombin, but is not necessary for all other conditions, including elevated factors XI and VIII.