A Turn-On and Colorimetric Probe Based on Isophorone Skeleton for Detecting Nerve Agent Mimic Diethyl Chlorophosphite.
Xue-Shuang YuMao-Mei ZhuRui ZuoYu PengYa-Wen WangPublished in: Molecules (Basel, Switzerland) (2023)
A new turn-on probe ( SWJT-20 ) based on isophorone fluorophore for the detection of nerve agent mimic diethyl chlorophosphite (DCP) was designed and synthesized. SWJT-20 could rapidly respond to DCP within 2 s using UV-Vis or fluorescent spectra, accompanied by a significant change in the solution color under visible light or UV light, which could be observed by the naked eyes. The detection limit of SWJT-20 to DCP was as low as 8.3 nM, which is lower than those of most reported fluorescent probes for DCP detection. Additionally, SWJT-20 could quantitatively measure DCP using ratio changes in A 427 /A 645 in absorption spectra. Furthermore, facile paper as sensors with the visualization of colorimetric/fluorometric responses based on SWJT-20 has been fabricated. Notably, this probe could detect DCP vapor through gas diffusion experiments.
Keyphrases
- living cells
- fluorescent probe
- label free
- visible light
- quantum dots
- single molecule
- loop mediated isothermal amplification
- real time pcr
- density functional theory
- photodynamic therapy
- gold nanoparticles
- optical coherence tomography
- hydrogen peroxide
- nitric oxide
- room temperature
- small molecule
- solid phase extraction
- ionic liquid