Construction and characterization of an improved DNA-launched infectious clone of duck hepatitis a virus type 1.
Junhao ChenRuihua ZhangShaoli LinPengfei LiJingjing LanZhijing XieYu WangShi-Jin JiangPublished in: Virology journal (2017)
We have constructed a genetically stable and highly pathogenic DNA-launched infectious clone, from which the rescued virus could be harvested by direct transfection with recombinant plasmids. rDHAV-1 shared similar growth characteristics and tissue tropism with pDHAV-1. The DNA-launched infectious system of DHAV-1 possessed higher rescue efficiency compared to the traditional RNA-launched infectious system.